Introduction: Paracetamol is a potent hepatotoxin and may cause severe acute hepatocellular injury.The present study was intended to assess the hepatoprotective potential of Caralluma umbellata Haw.(Asclepiadaceae) (C.umbellata) against paracetamol-induced hepatotoxicity in vitro and in Shorts vivo experimental models.Methods: Preliminary analysis
Streptolysin O Inhibits Clathrin-Dependent Internalization of Group A Streptococcus
ABSTRACT Group A Streptococcus (GAS) can be internalized by epithelial cells, including keratinocytes from human skin or pharyngeal epithelium.Internalization of GAS by epithelial cells has been postulated both to play a role in host defense and to provide a sanctuary site for GAS survival.The cholesterol-binding cytolysin streptolysin O (SLO) appe
Lottery Rank-Pruning Adaptation Parameter Efficient Fine-Tuning
Recent studies on parameter-efficient fine-tuning (PEFT) have introduced effective and efficient methods for fine-tuning large language models (LLMs) on downstream tasks using fewer parameters than required by full fine-tuning.Low-rank decomposition adaptation (LoRA) significantly reduces the parameter count to 0.03% of that in full fine-tuning, ma